Leftover Pizza Grilled Cheese

Featured in: Simple Weeknight Dinners

This easy-to-make dish combines cold pizza slices and juicy shredded chicken folded inside crispy grilled cheese. Buttered and toasted in a skillet until golden brown, the sandwich offers a rich, melty experience that turns leftovers into a comforting upgrade. Perfect as a quick snack or main, it’s a playful way to use day-old pizza with added protein and cheesy goodness.

Updated on Fri, 19 Dec 2025 12:48:00 GMT
Golden-brown Leftover Pizza Grilled Cheese with melted cheese and juicy chicken filling. Save
Golden-brown Leftover Pizza Grilled Cheese with melted cheese and juicy chicken filling. | dunebasil.com

My roommate came home with a cold pizza box and half a rotisserie chicken, and I was staring at both wondering what to do. Instead of reheating them separately like normal people, I grabbed a skillet and the butter dish, and something clicked—what if I treated leftover pizza like two perfect slices of bread? Ten minutes later, I was biting into something that tasted like the best decision I'd made all week.

I made this for my sister during a lazy Sunday afternoon when neither of us wanted to cook, and she took one bite and asked why I'd never told her about this combination before. That's when I realized it wasn't just convenient—it was genuinely delicious in a way that made you forget you were eating scraps.

Ingredients

  • Leftover pizza (2 large slices): Any style works, but a thicker, sturdier crust holds the filling better than thin crust—you want it to fold without cracking.
  • Cooked shredded chicken (1 cup): Rotisserie chicken is your shortcut here, still warm or cold, it doesn't matter much because the skillet will bring everything together.
  • Shredded mozzarella or cheddar (½ cup, optional): This is the wild card—extra cheese is never wrong, but skip it if your pizza already has plenty.
  • Unsalted butter (2 tbsp, softened): Softened butter spreads easier and creates that golden, crispy exterior that makes this special.

Instructions

Set up your canvas:
Pull your cold pizza slices out and lay them flat, cheese side facing up. This is your foundation—the bottom layer that's going to cradle all that chicken.
Build the filling:
Spread about half a cup of shredded chicken over each pizza slice's cheese side, pressing it down gently so it sticks. If you want extra decadence, sprinkle some additional cheese on top—it'll melt into everything.
Fold with intention:
Bring one edge of the pizza toward the other and press gently along the fold so it holds. You're not folding origami here; just gentle pressure keeps it sealed while it cooks.
Butter the outside:
Spread about a tablespoon of softened butter on the outside of each folded pizza half. Get it on both sides—that butter is what creates the crispy, golden shell you're after.
First side sear:
Heat your nonstick skillet over medium heat and place the folded pizzas in buttered side down. Let them sit for three to four minutes, listening for that gentle sizzle and watching for the golden-brown color to creep up the edges.
The flip and finish:
Use your spatula to flip each piece carefully, pressing down gently as you do. Cook the other side for another three to four minutes until the cheese inside is melted and oozing slightly, and the crust is evenly golden.
Rest and serve:
Slide them onto a plate and let them cool for just a minute—the insides are hot enough to burn your mouth if you rush. Slice each folded piece in half and serve while everything is still warm and crispy.
Crispy edges and a gooey cheese center: the ultimate Leftover Pizza Grilled Cheese ready to be enjoyed. Save
Crispy edges and a gooey cheese center: the ultimate Leftover Pizza Grilled Cheese ready to be enjoyed. | dunebasil.com

The moment I realized this was more than just a clever hack was when my friend reached for a second one without even asking. She didn't need to—I was already making another batch because watching someone's face light up over something this simple felt like the real win.

Pizza Choice Matters More Than You'd Think

Pepperoni pizza brings salt and fat that pairs beautifully with the chicken. Veggie pizza keeps things lighter but still flavorful. BBQ chicken pizza already has the chicken-pizza synergy built in, so the whole thing just sings. I've even tried it with plain cheese pizza from days old, and it still works because the butter and the new fillings do all the heavy lifting. The only pizza I'd skip is one that's been sitting around for more than three or four days—the crust gets stale in a way that no amount of butter can rescue.

Flavor Hacks That Actually Work

A small sprinkle of hot sauce folded inside turns this into something spicy and bold. Fresh herbs—basil, oregano, or even just a pinch of red pepper flakes—tucked into the filling bring an unexpected freshness. If you're dipping it, marinara sauce makes it feel intentional and restaurant-quality, while ranch dip plays into the comfort food angle. The best part is that none of these upgrades take extra time.

The Dipping Sauce Situation

I used to eat these plain, then I dipped one in marinara by accident and everything changed. Marinara brings you back to pizza territory—familiar and warming. Ranch is the comfort food move if you're not thinking too hard about it. Some people have even mentioned salsa, which I haven't tried yet but sounds like it could work if your pizza already has some kick to it.

  • Marinara is the classic choice and always feels like the right move.
  • Ranch works if you want something creamy and cool against the hot, crispy exterior.
  • A drizzle of hot sauce on the side gives you control over how much heat you're adding.
Enjoy a close-up of a perfectly grilled Leftover Pizza Grilled Cheese, ready for a comforting bite. Save
Enjoy a close-up of a perfectly grilled Leftover Pizza Grilled Cheese, ready for a comforting bite. | dunebasil.com

This became my go-to whenever I had leftovers piling up and no energy for cooking. It's the kind of recipe that feels like you're outsmarting your refrigerator, and it tastes good enough to feel like you're treating yourself.

Leftover Pizza Grilled Cheese

Melty grilled cheese filled with pizza slices and shredded chicken, toasted to crispy perfection.

Prep Time
5 minutes
Time to Cook
8 minutes
Overall Time
13 minutes
Recipe by Dune Basil Lea Romano


Skill Level Easy

Cuisine American

Makes 2 Portions

Diet Information None specified

What You'll Need

Main

01 2 large slices leftover pizza (any style with sturdy crust)
02 1 cup cooked shredded chicken (rotisserie or leftover)
03 ½ cup shredded mozzarella or cheddar cheese (optional)

For Toasting

01 2 tablespoons unsalted butter, softened

How to Make It

Step 01

Prepare pizza base: Place a cold pizza slice on a cutting board with the cheese side facing up.

Step 02

Add chicken and cheese: Evenly spread ½ cup cooked shredded chicken atop the cheese side of each pizza slice and sprinkle with additional shredded cheese if desired.

Step 03

Fold pizza slices: Fold each pizza slice in half gently, enclosing the chicken filling inside.

Step 04

Heat skillet and butter: Heat a large nonstick skillet over medium heat and spread 1 tablespoon softened butter on the outside of each folded pizza.

Step 05

Toast first side: Place the folded pizzas in the skillet, buttered side down, and cook for 3 to 4 minutes until golden brown and crisp.

Step 06

Toast second side: Flip the pizzas carefully, pressing gently with a spatula, and cook for an additional 3 to 4 minutes until cheese is melted and crust is browned.

Step 07

Rest and serve: Remove from heat, let rest for 1 minute, then slice in half and serve warm.

Essential Tools

  • Large nonstick skillet
  • Spatula
  • Knife and cutting board

Allergy Details

Review ingredients for allergies, and talk to your doctor if you're uncertain.
  • Contains wheat (pizza crust), milk (cheese, butter), possible eggs (pizza base or toppings), and chicken.
  • Check for soy or nuts in pizza and chicken if sensitive.

Nutrition per serving

Nutritional details are for reference only. They're not a substitute for medical advice.
  • Energy: 480
  • Fats: 23 g
  • Carbohydrates: 38 g
  • Proteins: 32 g